Daniel Mark, MD is an academic cardiologist engaging in clinical trials and outcomes research.

Research Publications

Dr. Mark has published over 330 peer-reviewed research articles, 30 editorials, and 80 book chapters.

PubMed provides a brief overview of each publication, along with links to the full research papers. Many publications are available free of charge.

Curriculum Vitae

The three key elements to research productivity are good coffee, an Apple, and some room to breathe. Not necessarily in that order.

Dr. Mark’s Curriculum Vitae (links to .pdf) provides a summary of his major career accomplishments thus far.


Daniel B. Mark, MD, MPH is a clinician-scientist with a 30-year career in health economics and outcomes research. He has been a pioneer in the incorporation of economic evaluations and patient reported outcomes into major cardiovascular mega-trials. He is also an experienced methodologist who has done extensive work involving risk adjustment and the incorporation of patient-reported quality of life outcomes into composite outcome measures of treatment effectiveness. In addition, he is a co-developer of the Duke Activity Status Index (DASI), which is one of the most often used patient reported outcome measures in patients with cardiac symptoms and disorders. Dr. Mark lectures internationally on health economics, quality of life outcomes, assessing quality of care, and the use of performance measures to influence physician behavior.

Since 1998 Dr. Mark has been a Professor of Medicine with tenure at Duke University. He is a senior faculty member in the Duke Clinical Research Institute and, in that organization, directs the largest academic Outcomes Research group in the world. Dr. Mark has numerous principal author publications in the top clinical research journals including the New England Journal of Medicine, Annals of Internal Medicine, JAMA, and Circulation. In 1997, he received the first Research Excellence Award given by the Association for Pharmacoeconomics and Outcomes Research, the leading academic professional organization in the outcomes field. Dr. Mark has also been honored by election into the American Society for Clinical Investigation (ASCI) and the Association of American Physicians (AAP), one of the few outcomes researchers to receive such recognition. In 2009, Dr. Mark received the American College of Cardiology’s Distinguished Scientist Award for his work in outcomes research.

Dr. Mark has been the principal investigator on major R01 grants from the NHLBI and the Agency for Health Research and Quality (AHRQ) with funding to do outcomes research from these organizations continuously since 1987. He is currently PI on four R01 grants from NHLBI that are incorporating economic evaluations and patient reported outcomes into major cardiovascular clinical trials. Each one of these trials is likely to have a major impact on clinical practice and health policy within the next decade. He is also Program Director of the Duke T32 Postdoctoral Training in Cardiovascular Clinical Research Program, along with Co-Director, Sana Al-Khatib, MD.

Dr. Mark has produced over 340 peer-reviewed original papers. He has also edited 2 books and has written 82 book chapters as well as numerous editorials. His work has been featured centrally in national clinical practice guidelines in the U.S. and abroad and prominently in some of the most prestigious medical textbooks. Dr. Mark lectures internationally and has given numerous plenary and keynote session talks at the American Heart Association annual scientific meetings and the American College of Cardiology annual meetings, the Canadian Cardiovascular Society, and European Society of Cardiology meetings. He has served and continues to serve on numerous national policy committees focused on improving quality and outcomes of cardiovascular care, including the American Heart Association’s Quality of Care and Outcomes Research Expert Panel and the American College of Cardiology’s Task Force on Clinical Data Standards as well as their Outcomes Assessment Subcommittee.

In 2015, he was appointed as Editor-in-Chief of the American Heart Journal, the oldest peer-review journal in cardiovascular medicine, and the leading cardiovascular journal (by impact factor) among those not affiliated with a major cardiovascular society. He served as the journal’s Editor from 1996-2015.

Dr. Mark also spends about 25% of his time in patient care and has a first hand understanding of the challenges and opportunities involved in using risk assessment and patient reported outcomes at the bedside and in the clinic.

Clinical Activities

Dr. Mark is a clinical cardiologist with the rank of Professor of Medicine in the Division of Cardiology, Department of Medicine at Duke University Medical Center.

He serves as Co-Director and attending physician on the Cardiac Care Unit at Duke University Medical Center and as a Medical Control Officer for the Duke Life Flight Transport Service.

His clinical interests include intensive cardiac care, acute myocardial infarction and unstable angina, and consultative cardiology.




1974 – B.A., Hampshire College

1978 – M.D., Tufts University School of Medicine

1979 – M.P.H., Harvard School of Public Health


1979 to 1980 – Internship in Internal Medicine, University of Virginia Hospital

1980 to 1982 – Residency in Internal Medicine, University of Virginia Hospital

1982 to 1985 – Fellowship in Cardiology, Duke University Medical Center

Diplomate American Board of Internal Medicine

1982 – Specialty, Internal Medicine

1985 – Subspecialty, Cardiology

Diplomate National Board of Medical Examiners

1980 – Certificate No. 199976

Medical Licensure

North Carolina #26308

Massachusetts #48121

Daniel Mark, MD attending on the Duke University Medical Center Coronary Care Unit.


Dr. Mark serves as attending physician on the coronary care unit at Duke University Medical Center.


Dr. Mark serves as a mentor both on the cardiac care unit and as Director of a post-doctoral training program in clinical research for cardiology Fellows pursing academic research careers.